PSI TargetDB

Statistics Summary Report for TB Center

Last updated: Feb 2 2012



Target Status Statistics

Total number of targets deposited by TB to TargetDB: 1836

      View TB Target List

Table 1: Status Statistics for TB

Status Total Number of Targets(%) Relative to "Cloned" Targets(%) Relative to "Expressed" Targets(%) Relative to "Purified" Targets(%) Relative to "Crystallized" Targets
Cloned1386100.0---
Expressed104075.0100.0--
Soluble61044.058.7--
Purified53038.251.0100.0-
Crystallized37326.935.970.4100.0
Diffraction-quality Crystals27820.126.752.574.5
Diffraction26619.225.650.271.3
NMR Assigned25718.524.748.5-
HSQC25818.624.848.7-
Crystal Structure25618.524.648.368.6
NMR Structure21015.220.239.6-
In PDB121015.220.239.60
Work Stopped131----
Test Target9----
Other8----

Last updated: Feb 2 2012


Note 1:   Number of targets with status "in PDB" may not be equal to number of structures determined by a project. A target may reference several PDB IDs (example: structure of the same polypeptides with different ligands). Multiple targets in TargetDB may identify the same PDB structure when a stucture is a result of collaboration between different centers and each center includes the target on its target list.

Table 2: Status Statistics for TB by Organism

These statistics are derived from mapping of target sequences to GenBank using >=98% sequence identity cut off.


Organism Total Number1 Work Stopped Cloned Expressed Purified Crystallized Crystal Structure NMR Structure In PDB
Bacteria179612713591023520364248205205
Prokaryota179612713591023520364248205205

Last updated: Feb 2 2012

Note 1:   Total counts in this table may differ from total number of targets and structures. A target is counted in different organism specifications if:
- a target is mapped to different organisms
- a target is a hybrid complex (for example:a complex of human and mouse polypeptides).

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Deposited Structure Statistics for TB Center

Number of Released X-Ray Structures: 484

Number of Released NMR Structures: 9

Total number of released structures from TB center in the PDB: 493

Table 3: PDB Status Statistics for Structures from TB

PDB StatusNumber of Structures
Total Deposited617
Released493
In Process124
Last updated: Feb 2 2012
Note 1:   "Total Deposited" are all structures in the PDB including structures released to the public and structures that are in the process to be released ("Released on Publication" , "Released on Certain Date", etc.).

Table 4: List of Structures Deposited in the PDB by TB

Total number of structures: 617

Structures of distinct targets: 3321

1   A target may reference several PDB IDs (example: structure of the same polypeptides with different ligands).
In this case only one structure is counted to compute number of structures of distinct targets.

Related PDB_ID(s): PDB_ID(s) associated with the same target in TargetDB.

PDB_ID TitleTarget_id Deposition DateReleased Date PDB StatusRelated PDB_ID in TargetDB
ND_184 Experimental status "in PDB", PDB ID is not providedrv1931c---none
ND_148 Experimental status "in PDB", PDB ID is not providedRv0490---none
ND_160 Experimental status "in PDB", PDB ID is not providedRv0867c---none
ND_222 Experimental status "in PDB", PDB ID is not providedRv3596c---none
ND_207 Experimental status "in PDB", PDB ID is not providedRv2917---none
ND_228 Experimental status "in PDB", PDB ID is not providedRv3718c---none
ND_122 Experimental status "in PDB", PDB ID is not providedRv1653---none
ND_131 Experimental status "in PDB", PDB ID is not providedRv3568c---none
ND_219 Experimental status "in PDB", PDB ID is not providedRv3426---none
ND_194 Experimental status "in PDB", PDB ID is not providedRv2351c---none
ND_233 Experimental status "in PDB", PDB ID is not providedRv3849---none
ND_198 Experimental status "in PDB", PDB ID is not providedRv2460c---none
ND_158 Experimental status "in PDB", PDB ID is not providedRv0808---none
ND_215 Experimental status "in PDB", PDB ID is not providedrv3286c---none
ND_230 Experimental status "in PDB", PDB ID is not providedRv3753c---none
ND_133 Experimental status "in PDB", PDB ID is not providedRv3616c---none
ND_151 Experimental status "in PDB", PDB ID is not providedRv0600c---none
ND_225 Experimental status "in PDB", PDB ID is not providedRv3648c---none
ND_171 Experimental status "in PDB", PDB ID is not providedRv1228---none
ND_116 Experimental status "in PDB", PDB ID is not providedRv0384c---none
ND_208 Experimental status "in PDB", PDB ID is not providedRv2988c---none
ND_120 Experimental status "in PDB", PDB ID is not providedRv0827c---none
ND_169 Experimental status "in PDB", PDB ID is not providedRv1124---none
ND_210 Experimental status "in PDB", PDB ID is not providedRv3015c---none
ND_162 Experimental status "in PDB", PDB ID is not providedRv0886---none
ND_192 Experimental status "in PDB", PDB ID is not providedRv2303c---none
ND_235 Experimental status "in PDB", PDB ID is not providedRv3922c---none
ND_182 Experimental status "in PDB", PDB ID is not providedRv1869c---none
ND_196 Experimental status "in PDB", PDB ID is not providedrv2416c---none
ND_129 Experimental status "in PDB", PDB ID is not providedRv3127---none
ND_188 Experimental status "in PDB", PDB ID is not providedRv2171---none
ND_153 Experimental status "in PDB", PDB ID is not providedRv0688---none
ND_200 Experimental status "in PDB", PDB ID is not providedRv2512c---none
ND_146 Experimental status "in PDB", PDB ID is not providedRv0414c---none
ND_213 Experimental status "in PDB", PDB ID is not providedRv3254---none
ND_167 Experimental status "in PDB", PDB ID is not providedRv1028c---none
ND_118 Experimental status "in PDB", PDB ID is not providedRv0634c---none
ND_203 Experimental status "in PDB", PDB ID is not providedRv2771c---none
ND_177 Experimental status "in PDB", PDB ID is not providedRv1595---none
ND_163 Experimental status "in PDB", PDB ID is not providedRv0890c---none
ND_136 Experimental status "in PDB", PDB ID is not providedRv0170---none
ND_143 Experimental status "in PDB", PDB ID is not providedRv0360c---none
ND_226 Experimental status "in PDB", PDB ID is not providedRv3705c---none
ND_173 Experimental status "in PDB", PDB ID is not providedRv1264---none
ND_180 Experimental status "in PDB", PDB ID is not providedRv1730c---none
ND_119 Experimental status "in PDB", PDB ID is not providedRv0693---none
ND_217 Experimental status "in PDB", PDB ID is not providedRv3396c---none
ND_114 Experimental status "in PDB", PDB ID is not providedRv0300---none
ND_141 Experimental status "in PDB", PDB ID is not providedRv0309---none
ND_220 Experimental status "in PDB", PDB ID is not providedrv3464---none
ND_205 Experimental status "in PDB", PDB ID is not providedRv2890c---none
ND_231 Experimental status "in PDB", PDB ID is not providedRv3789---none
ND_138 Experimental status "in PDB", PDB ID is not providedRv0252---none
ND_224 Experimental status "in PDB", PDB ID is not providedRv3647c---none
ND_124 Experimental status "in PDB", PDB ID is not providedRv2130c---none
ND_165 Experimental status "in PDB", PDB ID is not providedRv0990c---none
ND_214 Experimental status "in PDB", PDB ID is not providedRv3256c---none
ND_155 Experimental status "in PDB", PDB ID is not providedRv0772---none
ND_126 Experimental status "in PDB", PDB ID is not providedRv2855---none
ND_185 Experimental status "in PDB", PDB ID is not providedRv1966---none
ND_175 Experimental status "in PDB", PDB ID is not providedRv1350---none
ND_128 Experimental status "in PDB", PDB ID is not providedRv3020c---none
ND_132 Experimental status "in PDB", PDB ID is not providedRv3592---none
ND_150 Experimental status "in PDB", PDB ID is not providedRv0553---none
ND_212 Experimental status "in PDB", PDB ID is not providedRV3146---none
ND_134 Experimental status "in PDB", PDB ID is not providedRv0036C---none
ND_197 Experimental status "in PDB", PDB ID is not providedRv2449C---none
ND_140 Experimental status "in PDB", PDB ID is not providedRv0304c---none
ND_209 Experimental status "in PDB", PDB ID is not providedRv3013---none
ND_206 Experimental status "in PDB", PDB ID is not providedRv2891---none
ND_121 Experimental status "in PDB", PDB ID is not providedRv1030---none
ND_152 Experimental status "in PDB", PDB ID is not providedRv0601c---none
ND_236 Experimental status "in PDB", PDB ID is not providedRv3923c---none
ND_170 Experimental status "in PDB", PDB ID is not providedRv1184c---none
ND_157 Experimental status "in PDB", PDB ID is not providedRv0783c---none
ND_218 Experimental status "in PDB", PDB ID is not providedRv3415c---none
ND_166 Experimental status "in PDB", PDB ID is not providedRv1027c---none
ND_139 Experimental status "in PDB", PDB ID is not providedRv0278c---none
ND_193 Experimental status "in PDB", PDB ID is not providedrv2340c---none
ND_187 Experimental status "in PDB", PDB ID is not providedrv2108---none
ND_145 Experimental status "in PDB", PDB ID is not providedRv0368c---none
ND_154 Experimental status "in PDB", PDB ID is not providedrv0757---none
ND_159 Experimental status "in PDB", PDB ID is not providedRv0862c---none
ND_201 Experimental status "in PDB", PDB ID is not providedRv2660c---none
ND_115 Experimental status "in PDB", PDB ID is not providedRv0323c---none
ND_168 Experimental status "in PDB", PDB ID is not providedRv1085c---none
ND_179 Experimental status "in PDB", PDB ID is not providedrv1706c---none
ND_229 Experimental status "in PDB", PDB ID is not providedRv3735---none
ND_232 Experimental status "in PDB", PDB ID is not providedRv3835---none
ND_183 Experimental status "in PDB", PDB ID is not providedRv1884c---none
ND_223 Experimental status "in PDB", PDB ID is not providedRv3603c---none
ND_191 Experimental status "in PDB", PDB ID is not providedRv2294---none
ND_161 Experimental status "in PDB", PDB ID is not providedRv0871---none
ND_216 Experimental status "in PDB", PDB ID is not providedRv3302c---none
ND_195 Experimental status "in PDB", PDB ID is not providedrv2352c---none
ND_189 Experimental status "in PDB", PDB ID is not providedRv2179c---none
ND_117 Experimental status "in PDB", PDB ID is not providedRv0626---none
ND_127 Experimental status "in PDB", PDB ID is not providedRv2865---none
ND_149 Experimental status "in PDB", PDB ID is not providedRv0491---none
ND_211 Experimental status "in PDB", PDB ID is not providedRv3118---none
ND_174 Experimental status "in PDB", PDB ID is not providedRv1312---none
ND_221 Experimental status "in PDB", PDB ID is not providedrv3566c---none
ND_178 Experimental status "in PDB", PDB ID is not providedRv1604---none
ND_135 Experimental status "in PDB", PDB ID is not providedRv0145---none
ND_181 Experimental status "in PDB", PDB ID is not providedRv1814---none
ND_130 Experimental status "in PDB", PDB ID is not providedRv3526---none
ND_144 Experimental status "in PDB", PDB ID is not providedRv0363c---none
ND_202 Experimental status "in PDB", PDB ID is not providedRv2667---none
ND_234 Experimental status "in PDB", PDB ID is not providedRv3894c---none
ND_190 Experimental status "in PDB", PDB ID is not providedRv2257c---none
ND_125 Experimental status "in PDB", PDB ID is not providedRv2626c---none
ND_156 Experimental status "in PDB", PDB ID is not providedRv0777---none
ND_186 Experimental status "in PDB", PDB ID is not providedrv2059---none
ND_204 Experimental status "in PDB", PDB ID is not providedrv2790c---none
ND_113 Experimental status "in PDB", PDB ID is not providedRv0275c---none
ND_147 Experimental status "in PDB", PDB ID is not providedRv0436c---none
ND_142 Experimental status "in PDB", PDB ID is not providedRv0342---none
ND_137 Experimental status "in PDB", PDB ID is not providedRv0212c---none
ND_199 Experimental status "in PDB", PDB ID is not providedRv2468c---none
ND_176 Experimental status "in PDB", PDB ID is not providedrv1499---none
ND_172 Experimental status "in PDB", PDB ID is not providedRv1251c---none
ND_164 Experimental status "in PDB", PDB ID is not providedRv0989c---none
ND_123 Experimental status "in PDB", PDB ID is not providedRv1669---none
ND_227 Experimental status "in PDB", PDB ID is not providedRv3708c---none
2I6U crystal structure of ornithine carbamoyltransferase complexed with carbamoyl phosphate and l-norvaline from mycobacterium tuberculosis (rv1656) at 2.2 aRv16562006-08-292007-06-26REL2P2G
1YBT mycobacterium tuberculosis adenylyl cyclase, rv1900c chdRv1900c2004-12-212005-02-15REL1YBU
2JAX universal stress protein rv2623 from mycobaterium tuberculosisRv26232006-11-302007-12-11REL3CIS
2VBW feast or famine regulatory protein (rv3291c)from m. tuberculosis complexed with l-phenylalanineRv3291c2007-09-182007-11-06RELnone
2PKF crystal structure of m tuberculosis adenosine kinase (apo)Rv2202c TB:RV2202c2007-04-172007-06-19REL2PKK 2PKM
2Z76 x-ray crystal structure of rv0760c from mycobacterium tuberculosis at 1.82 angstrom resolutionRv0760c2007-08-162007-09-18RELnone
2FVH crystal structure of rv1848, a urease gamma subunit urea (urea amidohydrolase), from mycobacterium tuberculosisRv18482006-01-302006-02-07RELnone
3AAX crystal structure of probable thiosulfate sulfurtransferase cysa3 (rv3117) from mycobacterium tuberculosis: monoclinic formRv31172009-11-282009-12-08REL3AAY
1F8I crystal structure of isocitrate lyase:nitropropionate:glyoxylate complex from mycobacterium tuberculosisRv04672000-06-302000-12-30RELnone
2A7X crystal structure of a pantothenate synthetase complexed with amprv3602c2005-07-062006-02-21RELnone
1N2H crystal structure of a pantothenate synthetase from m. tuberculosis in complex with a reaction intermediate, pantoyl adenylaterv3602c2002-10-222003-04-22RELnone
1XXX crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosisRv2753c NON-XMTB:rv2753c2004-11-092006-02-14RELnone
2GKM crystal structure of mycobacterium tuberculosis trhbn tyrb10phe mutantRv1542C2006-04-032006-09-19RELnone
1WA8 solution structure of the cfp-10.esat-6 complex. major virulence determinants of pathogenic mycobacteriaRv3874 TB:Rv38752004-10-252005-06-27RELnone
1N8I biochemical and structural studies of malate synthase from mycobacterium tuberculosisRv1837c2002-11-202002-12-18REL1N8W 2GQ3
2O0B mycobacterium tuberculosis epsp synthase in complex with s3p (partially photolyzed)Rv32272006-11-272008-04-08RELnone
2VZY crystal structure of rv0802c from mycobacterium tuberculosis in an unliganded form.Rv0802c2008-08-072009-04-07REL2VZZ
2O2E mycobacterium tuberculosis tryptophan synthase beta subunit dimer (apoform)Rv16122006-11-292008-04-08REL2O2J
2NYX crystal structure of rv1404 from mycobacterium tuberculosisrv1404 ISFI:ISFI155 TB:Rv14042006-11-212006-12-05RELnone
1HX5 crystal structure of m. tuberculosis chaperonin-10Rv3418c2001-01-112001-08-08REL1P3H
3HFA crystal structure of mycobacterium tuberculosis proteasome open-gate mutantRv2109c2009-05-112009-09-15RELnone
3H6F crystal structure of mycobacterium tuberculosis proteasome modified by inhibitor ht1171Rv2110c2009-04-232009-09-15REL3H6I 3HF9
2BES structure of mycobacterium tuberculosis ribose-5-phosphate isomerase, rpib, rv2465c, in complex with 4-phospho-d-erythronohydroxamic acid.Rv2465c2004-11-302004-12-03RELnone
3HEM structure of mycobacterium tuberculosis mycolic acid cyclopropane synthase cmaa2 in complex with dioctylamineRv0503c2009-05-092009-06-16RELnone
2VBX feast or famine regulatory protein (rv3291c)from m. tuberculosis complexed with l-phenylalanineRv3291c2007-09-182007-11-06RELnone
2JCX x-ray structure of mutant 1-deoxy-d-xylulose 5-phosphate reductoisomerase, dxr, rv2870c, from mycobacterium tuberculosis, in complex with fosmidomycin and nadphRv2870c2007-01-042007-05-08RELnone
2IRY crystal structure of the polymerase domain from mycobacterium tuberculosis ligase d with dgtp and manganese.Rv09382006-10-162007-01-02RELnone
3HRH crystal structure of antigen 85c and glycerolRv0129c2009-06-092009-09-29RELnone
2WHI crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a purine analogue inhibitor and l-methionine-s- sulfoximine phosphate.Rv22202009-05-052009-09-01RELnone
1N8W biochemical and structural studies of malate synthase from mycobacterium tuberculosisRv1837c2002-11-212002-12-18RELnone
2PKM crystal structure of m tuberculosis adenosine kinase complexed with adenosineRv2202c TB:RV2202c2007-04-172007-06-26RELnone
1GSI crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with thymidine monophosphate (tmp)Rv3247c2002-01-032002-03-28RELnone
2GLN crystal structure of mycobacterium tuberculosis trhbn, glne11ala mutantRv1542C2006-04-052006-09-19RELnone
1MRN crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with bisubstrate inhibitor (tp5a)Rv3247c2002-09-182003-01-07RELnone
1S4Q crystal structure of guanylate kinase from mycobacterium tuberculosis (rv1389)Rv13892004-01-162004-01-27REL1Z8F 1ZNW 1ZNX 1ZNY
2CGQ a putative acyl carrier protein(rv0033) from mycobacterium tuberculosisRv00332006-03-092007-05-01RELnone
1YL7 the crystal structure of mycobacterium tuberculosis dihydrodipicolinate reductase (rv2773c) in complex with nadh (crystal form c)Rv2773c NON-XMTB:rv2773c2005-01-192006-01-17RELnone
2IYX shikimate kinase from mycobacterium tuberculosis in complex with shikimate and so4Rv2539c2006-07-222006-10-11RELnone
2A2J crystal structure of a putative pyridoxine 5'-phosphate oxidase (rv2607) from mycobacterium tuberculosisRv26072005-06-222005-08-23RELnone
1S8N crystal structure of rv1626 from mycobacterium tuberculosisRv1626 NON-XMTB:rv16262004-02-032004-09-21REL1SD5
1Z8F guanylate kinase double mutant a58c, t157c from mycobacterium tuberculosis (rv1389)Rv13892005-03-302005-04-12RELnone
1OZP crystal structure of rv0819 from mycobacterium tuberculosis mshd-mycothiol synthase acetyl-coenzyme a complex.Rv08192003-04-092003-09-09REL1P0H 2C27
1NKT crystal structure of the seca protein translocation atpase from mycobacterium tuberculosis complex with adpbsRv3240c2003-01-032003-03-04REL1NL3
1L4U crystal structure of shikimate kinase from mycobacterium tuberculosis in complex with mgadp and pt(ii) at 1.8 angstrom resolutionRv2539c2002-03-052002-06-12REL1L4Y 1U8A 1ZYU 2DFN 2DFT 2G1J 2G1K 2IYQ 2IYR 2IYS 2IYT 2IYU 2IYV 2IYW 2IYX
1YS7 crystal structure of the response regulator protein prra comlexed with mg2+Rv0903c NON-XMTB:rv0903c2005-02-072006-02-07RELnone
1UP2 structure of the endoglucanase cel6 from mycobacterium tuberculosis in complex with glucose-isofagomine at 1.9 angstromRv00622003-09-262004-11-18RELnone
2IYQ shikimate kinase from mycobacterium tuberculosis in complex with shikimate and adpRv2539c2006-07-212006-10-11RELnone
1GTV crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with thymidine-5'-diphosphate (tdp)Rv3247c2002-01-212002-03-28RELnone
1BVR m.tb. enoyl-acp reductase (inha) in complex with nad+ and c16-fatty-acyl-substrateRv14841998-09-171999-09-17REL1ENY 1ENZ 1P44 1P45 1ZID 2AQ8 2B35 2B36 2B37 2H7I 2H7L 2H7M 2H7N 2H7P 2NV6
1U9N crystal structure of the transcriptional regulator ethr in a ligand bound conformation opens therapeutic perspectives against tuberculosis and leprosyRv38552004-08-102004-11-16RELnone
2H7L crystal structure of mycobacterium tuberculosis enoyl reductase (inha) complexed with n-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamideRv14842006-06-022006-10-31RELnone
3DBO crystal structure of a member of the vapbc family of toxin-antitoxin systems, vapbc-5, from mycobacterium tuberculosisRv0627 ISFI:ISFI449 ISFI:ISFI4502008-06-022008-07-15RELnone
1YWF crystal structure of mycobacterium tuberculosis protein tyrosine phosphatase ptpbRv0153c2005-02-172005-11-22RELnone
2VG3 rv2361 with citronellyl pyrophosphateRv2361c2007-11-082008-05-06REL2VG4
1T56 crystal structure of tetr family repressor m. tuberculosis ethrRv38552004-05-032004-07-27REL1U9N 1U9O 3G1L 3G1M 3G1O
2H7P crystal structure of mycobacterium tuberculosis enoyl reductase (inha) complexed with n-(3-chloro-2-methylphenyl)-1-cyclohexyl- 5-oxopyrrolidine-3-carboxamideRv14842006-06-022006-10-31RELnone
2P2G crystal structure of ornithine carbamoyltransferase from mycobacterium tuberculosis (rv1656): orthorhombic formRv16562007-03-072007-07-03RELnone
1Y25 structure of mycobacterial thiol peroxidase tpxRv19322004-11-202005-11-20RELnone
1QPQ structure of quinolinic acid phosphoribosyltransferase from mycobacterium tuberculosis: a potential tb drug targetRv15961998-11-201998-11-25RELnone
1ZLJ crystal structure of the mycobacterium tuberculosis hypoxic response regulator dosr c-terminal domainRv3133c2005-05-062006-01-31REL1ZLK
1MOP crystal structure of a pantothenate synthetase from m. tuberculosisrv3602c2002-09-092003-03-11REL1N2B 1N2E 1N2G 1N2H 1N2I 1N2J 1N2O 2A7X 2A84 2A86 2A88 3IMC 3IME 3IMG 3IUB
1F61 crystal structure of isocitrate lyase from mycobacterium tuberculosisRv04672000-06-192000-08-30REL1F8I 1F8M
2C2X three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolas from mycobacterium tuberculosisRv3356c2005-09-302005-10-13REL2C2Y
1SGV structure of trna psi55 pseudouridine synthase (trub)Rv2793c2004-01-282004-02-10RELnone
1RTE x-ray structure of cyanide derivative of truncated hemoglobin n (trhbn) from mycobacterium tuberculosisRv1542C2003-12-102004-07-27RELnone
3BZQ high resolution crystal structure of nitrogen regulatory protein (rv2919c) of mycobacterium tuberculosisRv2919c2008-01-182008-04-01REL3LF0
2CCA crystal structure of the catalase-peroxidase (katg) and s315t mutant from mycobacterium tuberculosisRv1908C2006-01-162006-01-19RELnone
2A7Y solution structure of the conserved hypothetical protein rv2302 from the bacterium mycobacterium tuberculosisRv23022005-07-062005-08-23RELnone
2FP1 secreted chorismate mutase from mycobacterium tuberculosisRv1885c2006-01-152006-03-28RELnone
1DG5 dihydrofolate reductase of mycobacterium tuberculosis complexed with nadph and trimethoprimRv2763c1999-11-232000-03-09RELnone
1VS0 crystal structure of the ligase domain from m. tuberculosis ligd at 2.4aRv09382006-01-272006-02-28REL2IRU 2IRX 2IRY 2R9L
1LQU mycobacterium tuberculosis fpra in complex with nadphRv31062002-05-132002-07-31RELnone
3H87 rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosisRv0301 ISFI:ISFI521 ISFI:ISFI5222009-04-282009-05-05RELnone
3H7F crystal structure of serine hydroxymethyltransferase from mycobacterium tuberculosisRv1093 SSGCID:MytuD.00783.a2009-04-242009-05-05RELnone
2G1J crystal structure of mycobacterium tuberculosis shikimate kinase at 2.0 angstrom resolutionRv2539c2006-02-142006-07-18RELnone
1NL3 crystal structure of the seca protein translocation atpase from mycobacterium tuberculosis in apo formRv3240c2003-01-062003-03-04RELnone
1ZNW crystal structure of unliganded form of mycobacterium tuberculosis guanylate kinaseRv13892005-05-122005-11-29RELnone
2CIN lysine aminotransferase from m. tuberculosis in the internal aldimine formRv3290c2006-03-242006-08-14REL2CJD 2CJG 2CJH 2JJE 2JJF 2JJG
2FWV crystal structure of rv0813Rv0813c2006-02-032006-08-03RELnone
3EUL structure of the signal receiver domain of the putative response regulator narl from mycobacterium tuberculosisRv0844c2008-10-102008-11-11RELnone
2GQ2 mycobacterium tuberculosis thyx-nadp complexrv2754c2006-04-192006-06-27RELnone
1N2O crystal structure of pantothenate synthetase from m. tuberculosis, low occupancy of beta-alanine at the pantoate binding sitesrv3602c2002-10-232003-04-23RELnone
1RII crystal structure of phosphoglycerate mutase from m. tuberculosisRv04892003-11-172004-10-05RELnone
1HZP crystal structure of the myobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase iiiRv0533c2001-01-252001-06-13REL1M1M 2AHB 2AJ9
2GP6 x-ray crystal structure of mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase ii (mtkasb)Rv22462006-04-172006-07-18RELnone
1N4G structure of cyp121, a mycobacterial p450, in complex with iodopyrazoleRv22762002-10-312003-02-04RELnone
1P4S solution structure of mycobacterium tuberculosis adenylate kinaseRv07332003-04-242004-01-20RELnone
2GQ3 mycobacterium tuberculosis malate synthase in complex with magnesium, malate, and coenzyme aRv1837c2006-04-192006-08-15RELnone
2HYX structure of the c-terminal domain of dipz from mycobacterium tuberculosisRv28742006-08-082007-07-17RELnone
2VBZ feast or famine regulatory protein (rv3291c)from m. tuberculosis complexed with l-tryptophanRv3291c2007-09-182007-11-06RELnone
1U8R crystal structure of an ider-dna complex reveals a conformational change in activated ider for base-specific interactionsRv27112004-08-062004-10-05RELnone
2F6L x-ray structure of chorismate mutase from mycobacterium tuberculosisRv1885c2005-11-292005-12-13RELnone
2JEK crystal structure of the conserved hypothetical protein rv1873 from mycobacterium tuberculosis at 1.38 aRv18732005-09-212005-10-11RELnone
2H5X ruva from mycobacterium tuberculosisrv2593c2006-05-282006-08-15RELnone
1USL structure of mycobacterium tuberculosis ribose-5-phosphate isomerase, rpib, rv2465c, complexed with phosphate.Rv2465c NON-SPINE:rv2465c2003-11-252004-01-02REL2BES 2BET 2VVO 2VVP 2VVQ
1ZJ8 structure of mycobacterium tuberculosis nira proteinRv2391 NON-SPINE:Mtb12005-04-282005-05-31REL1ZJ9
3I59 crystal structure of mtbcrp in complex with n6-campRv36762009-07-032009-09-08RELnone
1W66 title withheldRv2217 NON-XMTB:rv22172004-08-132005-12-08RELnone
1TED crystal structure of a type iii polyketide synthase pks18 from mycobacterium tuberculosisRv13722004-05-252004-08-03REL1TEE
1E9X cytochrome p450 14 alpha-sterol demethylase (cyp51) from mycobacterium tuberculosis in complex with 4-phenylimidazoleRv0764c2000-10-302000-11-01REL1EA1 1H5Z 1U13 1X8V 2BZ9
2JD0 x-ray structure of mutant 1-deoxy-d-xylulose 5-phosphate reductoisomerase, dxr, rv2870c, from mycobacterium tuberculosis, in complex with nadphRv2870c2007-01-042007-05-08RELnone
2KFS nmr structure of rv2175cRv2175c2009-02-272009-05-19RELnone
3C8N crystal structure of apo-fgd1 from mycobacterium tuberculosisRv04072008-02-122008-04-22RELnone
1Z6K citrate lyase beta subunit complexed with oxaloacetate and magnesium from m. tuberculosisRv2498c TB:rv2498c2005-03-222005-05-03RELnone
3CE6 crystal structure of mycobacterium tuberculosis s-adenosyl-l-homocysteine hydrolase in ternary complex with nad and adenosineRv3248c2008-02-282008-09-16RELnone
2O0X mycobacterium tuberculosis epsp synthase in complex with intermediateRv32272006-11-282008-04-08RELnone
3E26 crystal structure of m. tuberculosis glucosyl-3-phosphoglycerate synthaseRv12082008-08-052008-12-02RELnone
2BM5 the structure of mfpa (rv3361c, p21 crystal form). the pentapeptide repeat protein from mycobacterium tuberculosis folds as a right- handed quadrilateral beta-helix.Rv3361c2005-03-092005-06-07RELnone
2IN8 crystal structure of mtu reca intein, splicing domainrv2737c2006-10-062007-05-01RELnone
2AQ6 x-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate at 1.7 a resolutionRv11552005-08-172005-08-30RELnone
1SNF mycobacterium tuberculosis dutpase complexed with magnesium and deoxyuridine 5'-monophosphateRv2697c2004-03-102004-03-16RELnone
1NFQ rv2002 gene product from mycobacterium tuberculosisRv20022002-12-152002-12-30RELnone
1XDI crystal structure of lpda (rv3303c) from mycobacterium tuberculosisRv3303c2004-09-062004-10-19RELnone
1XFC the 1.9 a crystal structure of alanine racemase from mycobacterium tuberculosis contains a conserved entryway into the active siterv3423c2004-09-142005-08-16RELnone
2CJG lysine aminotransferase from m. tuberculosis in bound pmp formRv3290c2006-04-012006-08-14RELnone
1Q7T rv1170 (mshb) from mycobacterium tuberculosisRv11702003-08-202004-01-13RELnone
1W2H crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with azidothymidine monophosphate (azt-mp) (2.0 a resolution)Rv3247c2004-07-062005-01-12RELnone
1ZNY crystal structure of mycobacterium tuberculosis guanylate kinase in complex with gdpRv13892005-05-122005-11-29RELnone
2VC1 feast or famine regulatory protein (rv3291c)from m. tuberculosis complexed with l-methionineRv3291c2007-09-182007-11-06RELnone
2H7N crystal structure of mycobacterium tuberculosis enoyl reductase (inha) complexed with n-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamideRv14842006-06-022006-10-31RELnone
1N2B crystal structure of a pantothenate synthetase from m. tuberculosis in complex with ampcpp and pantoate, higher occupancy of pantoate and lower occupancy of ampcpp in subunit arv3602c2002-10-222003-04-22RELnone
2GWR crystal structure of the response regulator protein mtra from mycobacterium tuberculosisRv3246c2006-05-052006-05-23RELnone
1X8V estriol-bound and ligand-free structures of sterol 14alpha-demethylase (cyp51)Rv0764c2004-08-182004-11-23RELnone
2O11 mycobacterium tuberculosis chorismate synthaseRv2540c2006-11-282008-04-08RELnone
2I3A crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase (rv1652) from mycobacterium tuberculosisRv16522006-08-172006-08-29REL2I3G 2NQT
1RLU mycobacterium tuberculosis ftsz in complex with gtp-gamma-srv2150c2003-11-262004-08-31REL1RQ2 1RQ7
1Q74 the crystal structure of 1d-myo-inosityl 2-acetamido-2-deoxy-alpha-d-glucopyranoside deacetylase (mshb)Rv11702003-08-152003-12-02REL1Q7T
1NFF crystal structure of rv2002 gene product from mycobacterium tuberculosisRv20022002-12-142002-12-30REL1NFQ 1NFR
1WQG crystal structure of ribosome recycling factor from mycobacterium tuberculosisRv2882c TB:rv2882c2004-09-292005-02-22RELnone
1W0D the high resolution structure of mycobacterium tuberculosis leub (rv2995c)Rv2995c NON-XMTB:rv2995c2004-06-032004-12-14RELnone
2W1A non-covalent complex between dahp synthase and chorismate mutase from mycobacterium tuberculosis with bound tsaRv0948c2008-10-162009-07-07RELnone
2B35 crystal structure of mycobacterium tuberculosis enoyl reductase (inha) inhibited by triclosanRv14842005-09-192006-03-07RELnone
1TQ8 crystal structure of protein rv1636 from mycobacterium tuberculosis h37rvRv1636 NYSGXRC:NYSGXRC-T15332004-06-162004-06-29RELnone
2DFT structure of shikimate kinase from mycobacterium tuberculosis complexed with adp and mg at 2.8 angstrons of resolutionRv2539c2006-03-032007-01-16RELnone
1N5J crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with thymidine diphosphate (tdp) and thymidine triphosphate (ttp) at ph 5.4 (1.85 a resolution)Rv3247c2002-11-062003-04-15RELnone
2ATW structure of a mycobacterium tuberculosis nusa-rna complexRv2841c2005-08-262005-10-11RELnone
2A86 crystal structure of a pantothenate synthetase complexed with amp and beta-alaninerv3602c2005-07-072006-02-21RELnone
3NO9 crystal structure of apo fumarate hydratase from mycobacterium tuberculosisRv1098c2010-06-252010-07-14RELnone
2A6P structure solution to 2.2 angstrom and functional characterisation of the open reading frame rv3214 from mycobacterium tuberculosisRv32142005-07-032006-05-16RELnone
3B4W crystal structure of mycobacterium tuberculosis aldehyde dehydrogenase complexed with nad+Rv0223c2007-10-242007-11-27RELnone
2A87 crystal structure of m. tuberculosis thioredoxin reductaseRv39132005-07-072005-11-29RELnone
2CCD crystal structure of the catalase-peroxidase (katg) and s315t mutant from mycobacterium tuberculosisRv1908C2006-01-162006-01-19RELnone
3ILW structure of dna gyrase subunit a n-terminal domainRv00062009-08-072009-10-06RELnone
2VFW rv1086 nativerv10862007-11-052007-11-13REL2VG0 2VG1 2VG2
3DCJ crystal structure of glycinamide formyltransferase (purn) from mycobacterium tuberculosis in complex with 5-methyl-5,6,7,8-tetrahydrofolic acid derivativeRv09562008-06-032009-05-12RELnone
2AO2 the 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactionsRv1885c2005-08-122006-06-13REL2F6L 2FP1 2FP2
2VZW x-ray structure of the heme-bound gaf domain of sensory histidine kinase dost of mycobacterium tuberculosisRv2027c2008-08-062009-03-17RELnone
2O0T the three dimensional structure of diaminopimelate decarboxylase from mycobacterium tuberculosis reveals a tetrameric enzyme organisationRv12932006-11-282007-02-13RELnone
1MO5 reca-atp-gamma-s-mg complexrv2737c2002-09-072003-02-18RELnone
1Q51 crystal structure of mycobacterium tuberculosis menb in complex with acetoacetyl-coenzyme a, a key enzyme in vitamin k2 biosynthesisRv0548c2003-08-052004-01-27REL1Q52 1RJM 1RJN
1F8M crystal structure of 3-bromopyruvate modified isocitrate lyase (icl) from mycobacterium tuberculosisRv04672000-06-302000-12-30RELnone
2AHB x-ray crystal structure of r46a,r161a mutant of mycobacterium tuberculosis fabhRv0533c2005-07-272005-08-23RELnone
2Z77 x-ray crystal structure of rv0760c from mycobacterium tuberculosis in complex with estradiol-17beta-hemisuccinateRv0760c2007-08-162007-09-18RELnone
1S61 crystal structure of ""truncated"" hemoglobin n (hbn) from mycobacterium tuberculosis, soaked with butyl-isocyanideRv1542C2004-01-222004-06-29RELnone
1EA1 cytochrome p450 14 alpha-sterol demethylase (cyp51) from mycobacterium tuberculosis in complex with fluconazoleRv0764c2000-11-022000-11-06RELnone
2JD1 x-ray structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase, dxr, rv2870c, from mycobacterium tuberculosis, in complex with manganese and nadphRv2870c2007-01-042007-05-08RELnone
1N40 atomic structure of cyp121, a mycobacterial p450Rv22762002-10-302003-02-04REL1N4G 2IJ7
2FHH crystal structure of mycobacterium tuberculosis proteasome in complex with a peptidyl boronate inhibitor mln-273Rv2109c2005-12-232006-02-28RELnone
2Z2I crystal structure of peptidyl-trna hydrolase from mycobacterium tuberculosisrv1014c2007-05-222007-07-24REL2Z2J 2Z2K
1ENY crystal structure and function of the isoniazid target of mycobacterium tuberculosisRv14841995-01-271996-01-29RELnone
2BJB mycobacterium tuberculosis epsp synthase in unliganded stateRv3227 NON-XMTB:rv32272005-02-012006-03-09REL2O0B 2O0D 2O0E 2O0X 2O0Z 2O15
2ZJF crystal structure of mycobacterium tuberculosis epoxide hydrolase b complexed with an inhibitorRv19382008-03-072008-04-01RELnone
2IB0 crystal structure of a conserved hypothetical protein, rv2844, from mycobacterium tuberculosisRv2844 ISFI:ISFI1952006-09-082006-09-26RELnone
1XVW crystal structure of ahpe from mycobacterium tuberculosis, a 1-cys peroxiredoxinRv2238c2004-10-282005-02-22REL1XXU
2C7G fpra from mycobacterium tuberculosis: his57gln mutantRv31062005-11-242006-07-26RELnone
1N2I crystal structure of pantothenate synthetase from m. tuberculosis in complex with a reaction intermediate, pantoyl adenylate, different occupancies of pantoyl adenylaterv3602c2002-10-222003-04-22RELnone
2ZJ1 crystal structure of mycobacterium tuberculosis s-adenosyl-l-homocysteine hydrolase in ternary complex with nad and 3'-keto-aristeromycinRv3248c2008-02-292008-09-16RELnone
2PFC structure of mycobacterium tuberculosis rv0098Rv00982007-04-042008-04-08RELnone
3LF0 crystal structure of the atp bound mycobacterium tuberculosis nitrogen regulatory pii proteinRv2919c2010-01-152010-07-07RELnone
2O0Z mycobacterium tuberculosis epsp synthase in complex with product (eps)Rv32272006-11-282008-04-08RELnone
1S56 crystal structure of ""truncated"" hemoglobin n (hbn) from mycobacterium tuberculosis, soaked with xe atomsRv1542C2004-01-202004-06-29RELnone
3HA3 crystal structure of hma (mmaa4) from mycobacterium tuberculosis complexed with s-adenosylhomocysteineRv0642c2009-05-012009-05-12REL3HA5 3HA7
1GN2 s123c mutant of the iron-superoxide dismutase from mycobacterium tuberculosis.Rv38462001-10-022001-10-05REL1GN3 1GN4 1GN6 1IDS
3DLA x-ray crystal structure of glutamine-dependent nad+ synthetase from mycobacterium tuberculosis bound to naad+ and donRv2438c2008-06-262009-03-10RELnone
1EYV the crystal structure of nusb from mycobacterium tuberculosisRv2533c2000-05-092000-05-18RELnone
3DA8 crystal structure of purn from mycobacterium tuberculosisRv09562008-05-282009-05-12REL3DCJ
2O2I crystal structure of haloalkane dehalogenase rv2579 from mycobacterium tuberculosis complexed with 1,3-propandiolRv25792006-11-292007-11-13RELnone
1NFR rv2002 gene product from mycobacterium tuberculosisRv20022002-12-162002-12-30RELnone
2VVP crystal structure of mycobacterium tuberculosis ribose-5-phosphate isomerase b in complex with its substrates ribose 5-phosphate and ribulose 5-phosphateRv2465c2008-06-102008-07-01RELnone
3B4Y fgd1 (rv0407) from mycobacterium tuberculosisRv04072007-10-252008-04-22REL3C8N
2G1K crystal structure of mycobacterium tuberculosis shikimate kinase in complex with shikimate at 1.75 angstrom resolutionRv2539c2006-02-142006-07-18RELnone
1TFU phosphopantetheine adenylyltransferase from mycobacterium tuberculosisRv2965c2004-05-272004-09-14RELnone
2I1U mycobacterium tuberculosis thioredoxin cRv39142006-08-152006-12-19RELnone
1L1E crystal structure of mycolic acid cyclopropane synthase pcaa complexed with s-adenosyl-l-homocysteineRv0470c2002-02-152002-03-06RELnone
2O0R the three-dimensional structure of n-succinyldiaminopimelate aminotransferase from mycobacterium tuberculosisRv0858c2006-11-282007-02-27RELnone
3FHZ crystal structure of the arginine repressor from mycobacterium tuberculosis bound with its dna operator and co-repressor, l-arginineRv16572008-12-102009-03-24RELnone
2ASF crystal structure of the conserved hypothetical protein rv2074 from mycobacterium tuberculosis 1.6 aRv20742005-08-232005-10-11RELnone
3FSY structure of tetrahydrodipicolinate n-succinyltransferase (rv1201c;dapd) in complex with succinyl-coa from mycobacterium tuberculosisRv1201c2009-01-122009-06-23RELnone
2O0D mycobacterium tuberculosis epsp synthase in complex with s3pRv32272006-11-272008-04-08RELnone
3C90 the 1.25 a resolution structure of phosphoribosyl-atp pyrophosphohydrolase from mycobacterium tuberculosis, crystal form iiRv2122c2008-02-142008-04-01RELnone
1RJN the crystal structure of menb (rv0548c) from mycobacterium tuberculosis in complex with the coa portion of naphthoyl coaRv0548c2003-11-192004-11-30RELnone
2IYV shikimate kinase from mycobacterium tuberculosis in complex with adp, open lid (conf. b)Rv2539c2006-07-222006-10-11RELnone
2BM6 the structure of mfpa (rv3361c, c2221 crystal form). the pentapeptide repeat protein from mycobacterium tuberculosis folds as a right- handed quadrilateral beta-helix.Rv3361c2005-03-092005-06-07RELnone
2IRU crystal structure of the polymerase domain from mycobacterium tuberculosis ligase dRv09382006-10-162007-01-02RELnone
2G38 a pe/ppe protein complex from mycobacterium tuberculosisRv2431c ISFI:ISFI141 ISFI:ISFI142 TB:rv2430c2006-02-172006-03-14RELnone
1P45 targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural dataRv14842003-04-212003-09-16RELnone
1Y3H crystal structure of inorganic polyphosphate/atp-nad kinase from mycobacterium tuberculosisRv16952004-11-242005-01-18RELnone
2A84 crystal structure of a pantothenate synthetase complexed with atprv3602c2005-07-072006-02-21RELnone
1IDS x-ray structure analysis of the iron-dependent superoxide dismutase from mycobacterium tuberculosis at 2.0 angstroms resolutions reveals novel dimer-dimer interactionsRv38461994-09-291994-12-20RELnone
1Y0H structure of rv0793 from mycobacterium tuberculosisRv07932004-11-152004-12-28RELnone
2CIG dihydrofolate reductase from mycobacterium tuberculosis inhibited by the acyclic 4r isomer of inh-nadp a derivative of the prodrug isoniazid.Rv2763c2006-03-202006-04-25RELnone
1ZVW the crystal structure of trpd (rv2192c) from mycobacterium tuberculosis in complex with prpp and magnesiumRv2192c2005-06-022006-01-17REL2BPQ
2QVB crystal structure of haloalkane dehalogenase rv2579 from mycobacterium tuberculosisRv25792007-08-082008-02-12RELnone
2FR2 crystal structure of rv2717c from m. tuberculosisRv2717c2006-01-182006-01-31RELnone
1N5L crystal structure of mycobacterium tuberculosis thymidylate kinase crystallized in sodium malonate, after catalysis in the crystal (2.3 a resolution)Rv3247c2002-11-062003-04-15RELnone
3DHY crystal structures of mycobacterium tuberculosis s-adenosyl-l-homocysteine hydrolase in ternary complex with substrate and inhibitorsRv3248c2008-06-192008-09-09RELnone
2G2D crystal structure of a putative pduo-type atp:cobalamin adenosyltransferase from mycobacterium tuberculosisRv1314c ISFI:ISFI152006-02-152006-03-28RELnone
1DG8 dihydrofolate reductase of mycobacterium tuberculosis complexed with nadphRv2763c1999-11-232000-03-09RELnone
3CTO crystal structure of m. tuberculosis yefm antitoxinRv33572008-04-142008-12-02REL3D55
1G2O crystal structure of purine nucleoside phosphorylase from mycobacterium tuberculosis in complex with a transition-state inhibitorRv33072000-10-202001-08-01REL1I80 1N3I
2IYR shikimate kinase from mycobacterium tuberculosis in complex with shikimateRv2539c2006-07-212006-10-11RELnone
1KPH crystal structure of mycolic acid cyclopropane synthase cmaa1 complexed with sah and dddmabRv3392c2001-12-302002-01-11RELnone
3IMG crystal structure of mycobacterium tuberculosis pantothenate synthetase at 1.8 ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acidrv3602c2009-08-102009-10-13RELnone
2PKK crystal structure of m tuberculosis adenosine kinase complexed with 2-fluro adenosineRv2202c TB:RV2202c2007-04-172007-06-19RELnone
1GR0 myo-inositol 1-phosphate synthase from mycobacterium tuberculosis in complex with nad and zinc.Rv0046c2001-12-102002-03-12RELnone
1XXU crystal structure of ahpe from mycrobacterium tuberculosis, a 1-cys peroxiredoxinRv2238c2004-11-082005-02-22RELnone
2JCZ x-ray structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase, dxr, rv2870c, from mycobacterium tuberculosis, in complex with fosmidomycin, manganese and nadphRv2870c2007-01-042007-05-08RELnone
3I93 crystal structure of mycobacterium tuberculosis dutpase stop138t mutantRv2697c2009-07-102009-11-24RELnone
2JJF n328a mutant of m. tuberculosis rv3290cRv3290c2008-04-042009-06-30RELnone
1LU4 1.1 angstrom resolution crystal structure of a secreted mycobacterium tuberculosis disulfide oxidoreductase homologous to e. coli dsbe: implications for functionsRv2878c2002-05-212003-10-14RELnone
1UE6 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisrv00542003-05-092004-02-10RELnone
1VA5 antigen 85c with octylthioglucoside in active siteRv0129c2004-02-112004-07-06RELnone
1HKV mycobacterium diaminopimelate dicarboxylase (lysa)Rv12932003-03-112003-03-20REL1HKW 2O0T
1NWA structure of mycobacterium tuberculosis methionine sulfoxide reductase a in complex with protein-bound methionineRv0137c TB:rv0137c2003-02-052003-07-08RELnone
2ZFZ crystal structure of the c-terminal domain hexamer of argr from mycobacterium tuberculosis in complex with arginineRv16572008-01-162008-02-12REL3BUE 3CAG 3ERE 3FHZ 3LAP
1UOZ structure of the endoglucanase cel6 from mycobacterium tuberculosis in complex with thiocellopentaose at 1.1 angstromRv00622003-09-262004-11-18REL1UP0 1UP2 1UP3
2E3J the crystal structure of epoxide hydrolase b (rv1938) from mycobacterium tuberculosis at 2.1 angstromRv19382006-11-272007-12-04REL2ZJF
3I54 crystal structure of mtbcrp in complex with campRv36762009-07-032009-09-08REL3I59
3HA5 crystal structure of hma (mmaa4) from mycobacterium tuberculosis complexed with sinefunginRv0642c2009-05-012009-05-12RELnone
2A11 crystal structure of nuclease domain of ribonuclase iii from mycobacterium tuberculosisRv2925c2005-06-172005-07-05RELnone
1G19 structure of reca proteinrv2737c2000-10-112000-12-11RELnone
2VP8 structure of mycobacterium tuberculosis rv1207Rv12072008-02-272008-08-12RELnone
1UE1 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisrv00542003-05-082004-02-10REL1UE5 1UE6 1UE7
1NGK crystallographic structure of mycobacterium tuberculosis hemoglobin oRv24702002-12-172003-05-20RELnone
1ZYU crystal structure of mycobacterium tuberculosis shikimate kinase in complex with shikimate and amppcp at 2.85 angstrom resolutionRv2539c2005-06-112006-07-11RELnone
1NH8 atp phosphoribosyltransferase (atp-prtase) from mycobacterium tuberculosis in complex with amp and histidineRv2121c2002-12-182003-02-11RELnone
1QPO quinolinate phosphoribosyl transferase (qaprtase) apo-enzyme from mycobacterium tuberculosisRv15961998-11-211998-11-24RELnone
2IYT shikimate kinase from mycobacterium tuberculosis in unliganded state, open lid (conf. a)Rv2539c2006-07-222006-10-11RELnone
1I80 crystal structure of m. tuberculosis pnp in complex with iminoribitol, 9-deazahypoxanthine and phosphate ionRv33072001-03-122001-08-01RELnone
1LMI 1.5 angstrom resolution crystal structure of a secreted protein from mycobacterium tuberculosis-mpt63Rv1926c2002-05-012002-12-04RELnone
2BZ9 ligand-free structure of sterol 14alpha-demethylase from mycobacterium tuberculosis in p2(1) space groupRv0764c2005-08-122006-12-07RELnone
1YK9 crystal structure of a mutant form of the mycobacterial adenylyl cyclase rv1625cRv1625c2005-01-172006-01-24RELnone
1GN4 h145e mutant of mycobacterium tuberculosis iron-superoxide dismutase.Rv38462001-10-022001-10-05RELnone
2GES pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a derivative, form-i (rt)Rv1092c2006-03-202006-06-06REL2GET 2GEU 2GEV
2GL3 crystal structure of mycobacterium tuberculosis trhbn, tyrb10phe glne11val mutantRv1542C2006-04-042006-09-19RELnone
2VG1 rv1086 e,e-farnesyl diphosphate complexrv10862007-11-072007-11-13RELnone
3F61 crystal structure of m. tuberculosis pknb leu33asp/val222asp double mutant in complex with adpRv0014c2008-11-052008-12-02RELnone
3BV0 crystal structure of plp bound 7,8-diaminopelargonic acid synthase in mycobacterium tuberculosisRv15682008-01-042008-02-05RELnone
2HHI the solution structure of antigen mpt64 from mycobacterium tuberculosis defines a novel class of beta-grasp proteinsRv1980c2006-06-282006-12-05RELnone
3GWC crystal structure of mycobacterium tuberculosis thymidylate synthase x bound to fdump and fadrv2754c SSGCID:MytuD.01655.a2009-03-312009-04-28RELnone
1YL5 crystal structure of mycobacterium tuberculosis dihydrodipicolinate reductase (rv2773c) (crystal form a)Rv2773c NON-XMTB:rv2773c2005-01-192006-01-17RELnone
2C2Y three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from mycobacterium tuberculosisRv3356c2005-09-302005-10-13RELnone
2IYW shikimate kinase from mycobacterium tuberculosis in complex with mgatp, open lid (conf. b)Rv2539c2006-07-222006-10-18RELnone
1PZS crystal structure of a cu-zn superoxide dismutase from mycobacterium tuberculosis at 1.63 resolutionRv04322003-07-142004-07-27RELnone
2O12 mycobacterium tuberculosis chorismate synthase in complex with fmnRv2540c2006-11-282008-04-08RELnone
1UP0 structure of the endoglucanase cel6 from mycobacterium tuberculosis in complex with cellobiose at 1.75 angstromRv00622003-09-262004-11-18RELnone
2IMZ crystal structure of mtu reca intein splicing domainrv2737c2006-10-052007-05-01RELnone
1UE5 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisrv00542003-05-092004-02-10RELnone
1RFE crystal structure of conserved hypothetical protein rv2991 from mycobacterium tuberculosisRv29912003-11-082004-12-28RELnone
2BET structure of mycobacterium tuberculosis ribose-5-phosphate isomerase, rpib, rv2465c, in complex with 4-phospho-d-erythronate.Rv2465c2004-11-302004-12-03RELnone
3EE4 r2-like ligand binding mn/fe oxidase from m. tuberculosisRv02332008-09-042009-04-07RELnone
3E25 crystal structure of m. tuberculosis glucosyl-3-phosphoglycerate synthaseRv12082008-08-052008-12-02REL3E26
1TEE crystal structure of c205f mutant of pks18 from mycobacterium tuberculosisRv13722004-05-252004-08-03RELnone
2IN0 crystal structure of mtu reca intein splicing domainrv2737c2006-10-052007-05-01RELnone
1YK3 crystal structure of rv1347c from mycobacterium tuberculosisRv1347c2005-01-162005-02-01RELnone
2IRX crystal structure of the polymerase domain from mycobacterium tuberculosis ligase d with gtp and manganese.Rv09382006-10-162007-01-02RELnone
2VG4 rv2361 nativeRv2361c2007-11-082007-11-27RELnone
3IUB crystal structure of pantothenate synthetase from mycobacterium tuberculosis in complex with 5-methoxy-n-(5-methylpyridin-2-ylsulfonyl)-1h-indole-2-carboxamiderv3602c2009-08-312009-10-13RELnone
1ZLK crystal structure of the mycobacterium tuberculosis hypoxic response regulator dosr c-terminal domain-dna complexRv3133c2005-05-062006-01-31RELnone
2H7M crystal structure of mycobacterium tuberculosis enoyl reductase (inha) complexed with 1-cyclohexyl-n-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamideRv14842006-06-022006-10-31RELnone
1WQF crystal structure of ribosome recycling factor from mycobacterium tuberculosisRv2882c TB:rv2882c2004-09-282005-02-22REL1WQG 1WQH
2KHR solution structure of rv2377c, a mbth-like protein from mycobacterium tuberculosisRv2377c SSGCID:MytuD.01649.a2009-04-102009-05-05RELnone
1U5V structure of cite complexed with triphosphate group of atp form mycobacterium tuberculosisRv2498c TB:rv2498c2004-07-282004-10-12RELnone
1PM7 rmlc (dtdp-6-deoxy-d-xylo-4-hexulose 3,5-epimerase)structure from mycobacterium tuberculosis and inhibitor design. the apo structure.Rv34652003-06-102003-12-09REL1UPI
2VC0 feast or famine regulatory protein (rv3291c)from m. tuberculosis complexed with l-leucineRv3291c2007-09-182007-11-06RELnone
1YBU mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex with a substrate analog.Rv1900c2004-12-212005-02-15RELnone
1QPN quinolinate phosphoribosyl transferase from mycobacterium tuberculosis in complex with ncnnRv15961998-11-201998-11-25REL1QPO 1QPQ 1QPR
2CJH lysine aminotransferase from m. tuberculosis in the internal aldimine form with bound substrate 2-ketoglutarateRv3290c2006-04-032006-08-14RELnone
1N2G crystal structure of a pantothenate synthetase from m. tuberculosis in complex with ampcpprv3602c2002-10-222003-04-22RELnone
2CJD lysine aminotransferase from m. tuberculosis in external aldimine formRv3290c2006-03-312006-08-14RELnone
1ZNX crystal structure of mycobacterium tuberculosis guanylate kinase in complex with gmpRv13892005-05-122005-11-29RELnone
1SM8 m. tuberculosis dutpase complexed with chromium and dutpRv2697c2004-03-082004-03-16RELnone
2NQT crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase (rv1652) from mycobacterium tuberculosis at 1.58 a resolutionRv16522006-10-312006-11-28RELnone
1N5K crystal structure of mycobacterium tuberculosis thymidylate kinase crystallized in sodium malonate (resolution 2.1 a)Rv3247c2002-11-062003-04-15RELnone
1MO4 reca-atp-gamma-s complexrv2737c2002-09-072003-02-18RELnone
3AAY crystal structure of probable thiosulfate sulfurtransferase cysa3 (rv3117) from mycobacterium tuberculosis: orthorhombic formRv31172009-11-282009-12-08RELnone
1KPG crystal structure of mycolic acid cyclopropane synthase cmaa1 complexed with sah and ctabRv3392c2001-12-302002-01-11RELnone
1SJ2 crystal structure of mycobacterium tuberculosis catalase-peroxidaseRv1908C2004-03-022004-07-20REL2CCA 2CCD
1SLH mycobacterium tuberculosis dutpase complexed with magnesium and dudpRv2697c2004-03-052004-03-16RELnone
1KPI crystal structure of mycolic acid cyclopropane synthase cmaa2 complexed with sah and dddmabRv0503c2001-12-302002-01-11REL3HEM
1ZEL crystal structure of rv2827c protein from mycobacterium tuberculosisRv2827c NON-XMTB:rv2827c2005-04-192006-05-02RELnone
2AP9 crystal structure of acetylglutamate kinase from mycobacterium tuberculosis cdc1551Rv1654 NYSGXRC:NYSGXRC-T17022005-08-152005-08-30RELnone
1K44 mycobacterium tuberculosis nucleoside diphosphate kinaseRv2445c2001-10-052002-05-15RELnone
3IME crystal structure of mycobacterium tuberculosis pantothenate synthetase at 2.40 ang resolution in complex with fragment compound 1-benzofuran-2-carboxylic acidrv3602c2009-08-102009-10-13RELnone
1U13 crystal structure analysis of the c37l/c151t/c442a-triple mutant of cyp51 from mycobacterium tuberculosisRv0764c2004-07-142004-07-27RELnone
2VZZ crystal structure of rv0802c from mycobacterium tuberculosis in complex with succinyl-coaRv0802c2008-08-072009-04-07RELnone
1FX7 crystal structure of the iron-dependent regulator (ider) from mycobacterium tuberculosisRv27112000-09-252001-03-07RELnone
1LQT a covalent modification of nadp+ revealed by the atomic resolution structure of fpra, a mycobacterium tuberculosis oxidoreductaseRv31062002-05-132002-07-31REL1LQU 2C7G
2G5F the structure of mbti from mycobacterium tuberculosis, the first enzyme in the synthesis of mycobactin, reveals it to be a salicylate synthaseRv2386c2006-02-222006-09-05REL2I6Y
2GKN crystal structure of mycobacterium tuberculosis trhbn, glne11val mutantRv1542C2006-04-032006-09-19RELnone
1EYE 1.7 angstrom resolution crystal structure of 6-hydroxymethyl-7,8-dihydropteroate synthase (dhps) from mycobacterium tuberculosis in complex with 6-hydroxymethylpterin monophosphateRv3608c2000-05-052000-10-11RELnone
2JCV x-ray structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase, dxr, rv2870c, from mycobacterium tuberculosis, in complex with fosmidomycin and nadphRv2870c2007-01-042007-05-08REL2JCX 2JCY 2JCZ 2JD0 2JD1 2JD2
3G1O ethr from mycobacterium tuberculosis in complex with compound bdm14500Rv38552009-01-302009-07-21RELnone
1SJP mycobacterium tuberculosis chaperonin60.2Rv04402004-03-042004-12-07RELnone
1ZTB crystal structure of chorismate synthase from mycobacterium tuberculosisRv2540c2005-05-262006-05-16REL2G85 2O11 2O12
3HQJ structure-function analysis of mycobacterium tuberculosis acyl carrier protein synthase (acps).Rv2523c2009-06-072009-09-15RELnone
1WQH crystal structure of ribosome recycling factor from mycobacterium tuberculosisRv2882c TB:rv2882c2004-09-292005-02-22RELnone
1TXO crystal structure of the mycobacterium tuberculosis serine/threonine phosphatase pstp/ppp at 1.95 a.Rv0018c2004-07-052004-11-23RELnone
1V0J udp-galactopyranose mutase from mycobacterium tuberculosisRv3809c2004-03-302005-01-26RELnone
1GN6 g152a mutant of mycobacterium tuberculosis iron-superoxide dismutase.Rv38462001-10-032001-10-05RELnone
2GEU pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a derivative, form-ii (rt)Rv1092c2006-03-202006-06-06RELnone
1U8A crystal structure of mycobacterium tuberculosis shikimate kinase in complex with shikimate and adp at 2.15 angstrom resolutionRv2539c2004-08-052004-10-19RELnone
1UP3 structure of the endoglucanase cel6 from mycobacterium tuberculosis in complex with methyl-cellobiosyl-4-deoxy-4-thio-beta-d-cellobioside at 1.6 angstromRv00622003-09-262004-11-18RELnone
1P0H crystal structure of rv0819 from mycobacterium tuberculosis mshd-mycothiol synthase coenzyme a complexRv08192003-04-102003-09-09RELnone
1P44 targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural dataRv14842003-04-212003-09-16RELnone
2Z2K crystal structure of peptidyl-trna hydrolase from mycobacterium tuberculosisrv1014c2007-05-222007-07-24RELnone
2C27 the structure of mycothiol synthase in complex with des- acetylmycothiol and coenzymea.Rv08192005-09-262005-12-01RELnone
1XVQ crystal structure of thiol peroxidase from mycobacterium tuberculosisRv19322004-10-282004-12-07REL1Y25
1DG7 dihydrofolate reductase of mycobacterium tuberculosis complexed with nadph and 4-bromo wr99210Rv2763c1999-11-232000-03-09RELnone
2VBY feast or famine regulatory protein (rv3291c)from m. tuberculosis complexed with l-tyrosineRv3291c2007-09-182007-11-06RELnone
3E3A the structure of rv0554 from mycobacterium tuberculosisRv05542008-08-062009-06-23RELnone
2BI0 x-ray structure of a conserved hypothetical protein, rv0216, from mycobacterium tuberculosis.Rv0216 NON-SPINE:rv02162005-01-202005-04-25RELnone
1GN3 h145q mutant of mycobacterium tuberculosis iron-superoxide dismutase.Rv38462001-10-022001-10-05RELnone
2NV6 mycobacterium tuberculosis inha (s94a) bound with inh-nad adductRv14842006-11-102006-11-21RELnone
1G18 reca-adp-alf4 complexrv2737c2000-10-112000-12-11REL1G19 1MO3 1MO4 1MO5 1MO6 2IMZ 2IN0 2IN8 2IN9
2ASB structure of a mycobacterium tuberculosis nusa-rna complexRv2841c2005-08-232005-10-11RELnone
3E53 crystal structure of n-terminal domain of a fatty acyl amp ligase faal28 from mycobacterium tuberculosisRv29412008-08-132009-01-27RELnone
1N2E crystal structure of a pantothenate synthetase from m. tuberculosis in complex with ampcpp and pantoaterv3602c2002-10-222003-04-22RELnone
2HH7 crystal structure of cu(i) bound csor from mycobacterium tuberculosis.Rv09672006-06-272006-12-05RELnone
2A15 x-ray crystal structure of rv0760 from mycobacterium tuberculosis at 1.68 angstrom resolutionRv0760c2005-06-172005-10-11REL2Z76 2Z77 2Z7A
3BUE crystal structure of the c-terminal domain hexamer of argr from mycobacterium tuberculosisRv16572008-01-022008-01-22RELnone
3H81 crystal structure of enoyl-coa hydratase from mycobacterium tuberculosisRv1070c SSGCID:MytuD.00358.a2009-04-282009-05-12RELnone
2IN9 crystal structure of mtu reca intein, splicing domainrv2737c2006-10-062007-05-01RELnone
2R9L polymerase domain from mycobacterium tuberculosis ligase d in complex with dnaRv09382007-09-132008-01-08RELnone
2BVC crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a transition state mimicRv22202005-06-232005-07-07RELnone
2W19 non-covalent complex between dahp synthase and chorismate mutase from mycobacterium tuberculosisRv0948c2008-10-162009-07-07RELnone
2FGG crystal structure of rv2632cRv2632c2005-12-212006-02-14RELnone
2DFN structure of shikimate kinase from mycobacterium tuberculosis complexed with adp and shikimate at 1.9 angstrons of resolutionRv2539c2006-03-032006-09-03RELnone
1P3H crystal structure of the mycobacterium tuberculosis chaperonin 10 tetradecamerRv3418c2001-06-272001-09-05RELnone
1DQZ crystal structure of antigen 85c from mycobacterium tuberculosisRv0129c2000-01-052000-07-12RELnone
1HTO crystallographic structure of a relaxed glutamine synthetase from mycobacterium tuberculosisRv22202001-01-012002-07-24REL1HTQ 2BVC 2WGS 2WHI
1NYO solution structure of the antigenic tb protein mpt70/mpb70Rv28752003-02-132003-08-19RELnone
3IMC crystal structure of mycobacterium tuberculosis pantothenate synthetase at 1.6 ang resolution in complex with fragment compound 5-methoxyindole, sulfate and glycerolrv3602c2009-08-102009-10-13RELnone
1YSR crystal structure of atp binding domain of prrb from mycobacterium tuberculosisRv0902c NON-XMTB:rv0902c2005-02-092005-07-12RELnone
1PC3 crystal structure of the extracellular phosphate abc transport receptor (psts-1) and immunodominant antigen of m. tuberculosis.Rv09342003-05-152004-05-18RELnone
2FP2 secreted chorismate mutase from mycobacterium tuberculosisRv1885c2006-01-152006-03-28RELnone
1SMC mycobacterium tuberculosis dutpase complexed with dutp in the absence of metal ion.Rv2697c2004-03-092004-03-16RELnone
1KP9 crystal structure of mycolic acid cyclopropane synthase cmaa1, apo-formRv3392c2001-12-302002-01-11REL1KPG 1KPH
2A88 crystal structure of a pantothenate synthetase, apo enzyme in c2 space grouprv3602c2005-07-072006-02-21RELnone
2BMX mycobacterium tuberculosis ahpcRv2428 NON-SPINE:IPRv2428PALZ2005-03-162005-05-10RELnone
2QBV crystal structure of intracellular chorismate mutase from mycobacterium tuberculosisRv0948c2007-06-182007-06-26REL2W19 2W1A
1KLP the solution structure of acyl carrier protein from mycobacterium tuberculosisRv22442001-12-122002-06-07RELnone
1SR9 crystal structure of leua from mycobacterium tuberculosisRv37102004-03-222004-05-18RELnone
2FHG crystal structure of mycobacterial tuberculosis proteasomeRv2109c2005-12-232006-02-28REL2FHH 3HFA
1M1M x-ray crystal structure of mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase iii (mtfabh)Rv0533c2002-06-192002-07-17RELnone
3D55 crystal structure of m. tuberculosis yefm antitoxinRv33572008-05-152008-12-02RELnone
3G1L ethr from mycobacterium tuberculosis in complex with compound bdm14744Rv38552009-01-302009-07-21RELnone
1IDR crystal structure of the truncated-hemoglobin-n from mycobacterium tuberculosisRv1542C2001-04-052001-08-22REL1RTE 1S56 1S61 2GKM 2GKN 2GL3 2GLN
1XSF solution structure of a resuscitation promoting factor domain from mycobacterium tuberculosisRv10092004-10-192005-02-15RELnone
1Z9W tetrameric structure of apo-7,8-dihydroneopterin aldolase from mycobacterium tuberculosisRv3607c2003-10-212004-11-02RELnone
3HF9 crystal structure of mycobacterium tuberculosis proteasome open-gate mutant modified by inhibitor gl1Rv2110c2009-05-112009-09-15RELnone
2BM4 the structure of mfpa (rv3361c, c2 crystal form). the pentapeptide repeat protein from mycobacterium tuberculosis folds as a right- handed quadrilateral beta-helix.Rv3361c2005-03-092005-06-07REL2BM5 2BM6 2BM7
2I3G crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase (rv1652) from mycobacterium tuberculosis in complex with nadp+.Rv16522006-08-182006-09-05RELnone
1Y6X the 1.25 a resolution structure of phosphoribosyl-atp pyrophosphohydrolase from mycobacterium tuberculosisRv2122c2004-12-072005-03-01REL3C90
1YGY crystal structure of d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosisRv2996c2005-01-052005-01-25RELnone
2VG0 rv1086 citronelly pyrophosphate complexrv10862007-11-072007-11-13RELnone
3B4T crystal structure of mycobacterium tuberculosis rnase ph, the mycobacterium tuberculosis structural genomics consortium target rv1340Rv13402007-10-242007-11-20RELnone
2B7O the structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosisRv2178c2005-10-052005-10-18RELnone
3G1M ethr from mycobacterium tuberculosis in complex with compound bdm31381Rv38552009-01-302009-07-21RELnone
1ZJ9 structure of mycobacterium tuberculosis nira proteinRv23912005-04-282005-05-31RELnone
2FSX crystal structure of rv0390 from m. tuberculosisRv03902006-01-232006-02-07RELnone
2IJ7 structure of mycobacterium tuberculosis cyp121 in complex with the antifungal drug fluconazoleRv22762006-09-292006-11-07RELnone
1ZZO structure of mtb dsbf in its oxidized form.Rv16772005-06-142005-07-26RELnone
2B37 crystal structure of mycobacterium tuberculosis enoyl reductase (inha) inhibited by 5-octyl-2-phenoxyphenolRv14842005-09-192006-03-07RELnone
1U0R crystal structure of mycobacterium tuberculosis nad kinaseRv16952004-07-142004-08-31REL1U0T 1Y3H 1Y3I
1UPI mycobacterium tuberculosis rmlc epimerase (rv3465)Rv34652003-10-052003-10-07RELnone
1DQY crystal structure of antigen 85c from mycobacterium tuberculosis with diethyl phosphate inhibitorRv0129c2000-01-052000-07-12REL1DQZ 1VA5 3HRH
1NBU 7,8-dihydroneopterin aldolase complexed with product from mycobacterium tuberculosisRv3607c2002-12-032004-01-13REL1Z9W
1ME5 crystal structure of mycobacterium tuberculosis alkylperoxidase ahpd h132q mutantRv24292002-08-082002-09-11RELnone
1R88 the crystal structure of mycobacterium tuberculosis mpt51 (fbpc1)Rv3803c2003-10-232003-12-30RELnone
2ZJ0 crystal structure of mycobacterium tuberculosis s-adenosyl-l-homocysteine hydrolase in ternary complex with nad and 2-fluoroadenosineRv3248c2008-02-292008-09-16RELnone
3CIS the crystal structure of rv2623 from mycobacterium tuberculosisRv26232008-03-112009-03-17RELnone
2H7I crystal structure of mycobacterium tuberculosis enoyl reductase (inha) complexed with 1-cyclohexyl-5-oxo-n-phenylpyrrolidine-3-carboxamideRv14842006-06-022006-10-31RELnone
2JJE crystal structure of t330s mutant of rv3290c from m. tuberculosisRv3290c2008-04-032009-06-30RELnone
1W30 pyrr of mycobacterium tuberculosis as a potential drug targetRv13792004-07-112004-09-29RELnone
2O2H crystal structure of haloalkane dehalogenase rv2579 from mycobacterium tuberculosis complexed with 1,2-dichloroethaneRv25792006-11-292007-11-13REL2O2I 2QVB
1F0N mycobacterium tuberculosis antigen 85bRv1886c2000-05-162001-01-24REL1F0P
3ERE crystal structure of the arginine repressor protein from mycobacterium tuberculosis in complex with the dna operatorRv16572008-10-012008-10-14RELnone
1B1B iron dependent regulatorRv27111998-11-191999-12-03REL1FX7 1U8R
2ZQ5 crystal structure of sulfotransferase stf1 from mycobacterium tuberculosis h37rv (type1 form)Rv3529c2008-08-062009-09-29RELnone
1HTQ multicopy crystallographic structure of a relaxed glutamine synthetase from mycobacterium tuberculosisRv22202001-01-012002-07-24RELnone
1OY0 the crystal structure of the first enzyme of pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase from mycobacterium tuberculosis shows a decameric assembly and terminal helix-swappingRv22252003-04-032003-07-15RELnone
2ZHX crystal structure of uracil-dna glycosylase from mycobacterium tuberculosis in complex with a proteinaceous inhibitorrv2976c2008-02-112008-05-20RELnone
1P9L structure of m. tuberculosis dihydrodipicolinate reductase in complex with nadh and 2,6 pdcRv2773c2003-05-122003-08-26RELnone
1MRS crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with 5-ch2oh deoxyuridine monophosphateRv3247c2002-09-182003-01-07RELnone
3HT5 crystal structure of ilve a branched chain amino acid transaminase from mycobacterium tuberculosisRv2210c2009-06-112009-12-01RELnone
2IYU shikimate kinase from mycobacterium tuberculosis in complex with adp, open lid (conf. a)Rv2539c2006-07-222006-10-11RELnone
3FSX structure of tetrahydrodipicolinate n-succinyltransferase (rv1201c; dapd) from mycobacterium tuberculosisRv1201c2009-01-122009-06-23REL3FSY
2G9W crystal structure of rv1846c, a putative transcriptional regulatory protein of mycobacterium tuberculosisRv1846c2006-03-072007-03-13RELnone
3DWG crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of mycobacterium tuberculosisRv13352008-07-222008-09-23RELnone
3HZG crystal structure of mycobacterium tuberculosis thymidylate synthase x bound with fadrv2754c2009-06-232009-07-07RELnone
2JCY x-ray structure of mutant 1-deoxy-d-xylulose 5-phosphate reductoisomerase, dxr, rv2870c, from mycobacterium tuberculosisRv2870c2007-01-042007-05-08RELnone
2QZ8 crystal structure of mycobacterium tuberculosis leucine response regulatory protein (lrpa)Rv3291c2007-08-162007-11-06REL2VBW 2VBX 2VBY 2VBZ 2VC0 2VC1
2B36 crystal structure of mycobacterium tuberculosis enoyl reductase (inha) inhibited by 5-pentyl-2-phenoxyphenolRv14842005-09-192006-03-07RELnone
1NXJ structure of rv3853 from mycobacterium tuberculosisRv38532003-02-102003-07-29RELnone
2O0E mycobacterium tuberculosis epsp synthase in complex with s3p and pepRv32272006-11-272008-04-08RELnone
1MQ7 crystal structure of dutpase from mycobacterium tuberculosis (rv2697c)Rv2697c2002-09-132002-10-09REL1SIX 1SJN 1SLH 1SM8 1SMC 1SNF 3H6D 3I93
1TPY structure of the cyclopropane synthase mmaa2 from mycobacterium tuberculosisRv0644c2004-06-162004-10-19RELnone
1SFR crystal structure of the mycobacterium tuberculosis antigen 85a proteinRv3804c2004-02-202004-07-06RELnone
2VVO crystal structure of mycobacterium tuberculosis ribose-5-phosphate isomerase b in complex with alpha allose 6-phosphateRv2465c2008-06-102008-07-01RELnone
2Z2J crystal structure of peptidyl-trna hydrolase from mycobacterium tuberculosisrv1014c2007-05-222007-07-24RELnone
2ZIZ crystal structure of mycobacterium tuberculosis s-adenosyl-l-homocysteine hydrolase in ternary complex with nad and 3-deazaadenosineRv3248c2008-02-292008-09-16REL2ZJ0 2ZJ1 3CE6 3DHY
1Y8T crystal structure of rv0983 from mycobacterium tuberculosis- proteolytically active formRv09832004-12-132005-01-18RELnone
2JD2 x-ray structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase, dxr, rv2870c, from mycobacterium tuberculosis, in complex with manganeseRv2870c2007-01-042007-05-08RELnone
3H6D structure of the mycobacterium tuberculosis dutpase d28n mutantRv2697c2009-04-232009-11-24RELnone
2BCF crystal structure of a evolved putative penicillin-binding protein homolog, rv2911, from mycobacterium tuberculosis.Rv29112005-10-192005-10-25RELnone
1ENZ crystal structure and function of the isoniazid target of mycobacterium tuberculosisRv14841995-01-271996-01-29RELnone
1XXO x-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase at 1.8 a resolutionRv11552004-11-072004-11-16RELnone
1YLK crystal structure of rv1284 from mycobacterium tuberculosis in complex with thiocyanateRv1284 NON-SPINE:Rv12842005-01-192005-03-08RELnone
1YS3 crystal structure of the atp binding domain of prrb from mycobacterium tuberculosisRv0902c NON-XMTB:rv0902c2005-02-072005-07-12REL1YSR
1RQ2 mycobacterium tuberculosis ftsz in complex with citraterv2150c2003-12-042004-08-31RELnone
3H6I crystal structure of mycobacterium tuberculosis proteasome modified by inhibitor gl1Rv2110c2009-04-232009-09-15RELnone
2O15 mycobacterium tuberculosis epsp synthase after partial products withdrawalRv32272006-11-282008-04-08RELnone
1N2J crystal structure of a pantothenate synthetase from m. tuberculosis in complex with pantoaterv3602c2002-10-222003-04-22RELnone
2VVQ crystal structure of mycobacterium tuberculosis ribose-5-phosphate isomerase b in complex with the inhibitor 5-deoxy-5-phospho-d- ribonateRv2465c2008-06-102008-07-01RELnone
2JJG crystal structure of the m. tuberculosis lysine-epsilon aminotransferase (rv3290c) complexed to an inhibitorRv3290c2008-04-042009-06-30RELnone
1YS6 crystal structure of the response regulatory protein prra from mycobacterium tuberculosisRv0903c NON-XMTB:rv0903c2005-02-072006-02-07REL1YS7
2O2J mycobacterium tuberculosis tryptophan synthase beta chain dimer (apoform)Rv16122006-11-292008-04-08RELnone
2I6Y structure and mechanism of mycobacterium tuberculosis salicylate synthase, mbtiRv2386c2006-08-292007-06-19RELnone
1HKW mycobacterium diaminopimelate dicarboxylase (lysa)Rv12932003-03-112003-03-18RELnone
1Y30 x-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase complexed with flavin mononucleotide at 2.2 a resolutionRv11552004-11-232005-08-30RELnone
3F69 crystal structure of the mycobacterium tuberculosis pknb mutant kinase domain in complex with kt5720Rv0014c2008-11-052008-12-02RELnone
2AQ8 crystal structure of wild-type of enoyl-acp(coa) reductase from mycobacterium tuberculosis in complex with nadh.Rv14842005-08-172006-05-23RELnone
3FVE crystal structure of diaminopimelate epimerase mycobacterium tuberculosis dapfRv2726c2009-01-152009-01-27RELnone
3CAG crystal structure of the oligomerization domain hexamer of the arginine repressor protein from mycobacterium tuberculosis in complex with 9 arginines.Rv16572008-02-192008-03-18RELnone
1QPR quinolinate phosphoribosyltransferase (qaprtase) from mycobacterium tuberculosis in complex with phthalate and prpcpRv15961998-10-171998-10-21RELnone
1NH7 atp phosphoribosyltransferase (atp-prtase) from mycobacterium tuberculosisRv2121c2002-12-182003-02-11REL1NH8
1Q52 crystal structure of mycobacterium tuberculosis menb, a key enzyme in vitamin k2 biosynthesisRv0548c2003-08-052004-01-27RELnone
1U9O crystal structure of the transcriptional regulator ethr in a ligand bound conformationRv38552004-08-102004-11-16RELnone
1C3V dihydrodipicolinate reductase from mycobacterium tuberculosis complexed with nadph and pdcRv2773c1999-07-282003-08-26REL1P9L 1YL5 1YL6 1YL7
1MRU intracellular ser/thr protein kinase domain of mycobacterium tuberculosis pknb.Rv0014c2002-09-182003-02-11REL1O6Y 3F61 3F69
2VG2 rv2361 with ipprv10862007-11-072007-11-13RELnone
3LAP the structure of the intermediate complex of the arginine repressor from mycobacterium tuberculosis bound to its dna operator and l-canavanine.Rv16572010-01-062010-05-05RELnone
2GEV pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a derivative, form-ii (lt)Rv1092c2006-03-202006-06-06RELnone
1GU9 crystal structure of mycobacterium tuberculosis alkylperoxidase ahpdRv24292002-01-242002-02-14REL1KNC 1LW1 1ME5
1I9G crystal structure of an adomet dependent methyltransferaseRv2118c2001-03-202001-09-26RELnone
2IYS shikimate kinase from mycobacterium tuberculosis in complex with shikimate, open lid (conf. a)Rv2539c2006-07-212006-10-11RELnone
3LWB crystal structure of apo d-alanine:d-alanine ligase (ddl) from mycobacterium tuberculosisRv2981c2010-02-232010-03-09RELnone
1ZID long fatty acid chain enoyl-acp reductase (inha) in complex with an isonicotinic-acyl-nadh inhibitorRv14841997-03-251998-03-25RELnone
2BM7 the structure of mfpa (rv3361c, p3221 crystal form). the pentapeptide repeat protein from mycobacterium tuberculosis folds as a right- handed quadrilateral beta-helix.Rv3361c2005-03-092005-06-07RELnone
1F0P mycobacterium tuberculosis antigen 85b with trehaloseRv1886c2000-05-162001-01-24RELnone
1YL6 crystal structure of mycobacterium tuberculosis dihydrodipicolinate reductase (rv2773c) (crystal form b)Rv2773c NON-XMTB:rv2773c2005-01-192006-01-17RELnone
1SIX mycobacterium tuberculosis dutpase complexed with magnesium and alpha,beta-imido-dutpRv2697c2004-03-012004-03-09RELnone
1U0T crystal structure of mycobacterium tuberculosis nad kinaseRv16952004-07-142004-08-31RELnone
2GDN crystal structure of the mycobacterium tuberculosis beta-lactamaseRv2068c2006-03-162006-04-18RELnone
1KNC structure of ahpd from mycobacterium tuberculosis, a novel enzyme with thioredoxin-like activity.Rv24292001-12-182002-01-23RELnone
1MO3 reca-adp complexrv2737c2002-09-072003-02-18RELnone
1RJM crystal structure of menb (rv0548c) from mycobacterium tuberculosisRv0548c2003-11-192004-11-30RELnone
1L4Y crystal structure of shikimate kinase from mycobacterium tuberculosis in complex with mgadp at 2.0 angstrom resolutionRv2539c2002-03-062002-06-12RELnone
1W9A crystal structure of rv1155 from mycobacterium tuberculosisRv11552004-10-072005-01-06REL1XXO 1Y30 2AQ6
1UE7 crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosisrv00542003-05-092004-02-10RELnone
1K0R crystal structure of mycobacterium tuberculosis nusaRv2841c2001-09-202001-12-21REL2ASB 2ATW
1LW1 crystal structure of mycobacterium tuberculosis alkylperoxidase ahpd h137f mutantRv24292002-05-302002-07-17RELnone
1SJN mycobacterium tuberculosis dutpase complexed with magnesium and alpha,beta-imido-dutpRv2697c2004-03-042004-03-09RELnone
1SD5 crystal structure of rv1626Rv1626 NON-XMTB:rv16262004-02-132004-09-21RELnone
1RWI extracellular domain of mycobacterium tuberculosis pkndRv0931c2003-12-162004-04-27REL1RWL
1RWL extracellular domain of mycobacterium tuberculosis pkndRv0931c2003-12-162004-04-27RELnone
1Y3I crystal structure of mycobacterium tuberculosis nad kinase-nad complexRv16952004-11-252005-01-18RELnone
1MO6 reca-datp-mg complexrv2737c2002-09-072003-02-18RELnone
2AF6 crystal structure of mycobacterium tuberculosis flavin dependent thymidylate synthase (mtb thyx) in the presence of co-factor fad and substrate analog 5-bromo-2'-deoxyuridine-5'-monophosphate (brdump)rv2754c2005-07-252005-10-04REL2GQ2 3GWC 3HZG
2GET pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a derivative, form-i (lt)Rv1092c2006-03-202006-06-06RELnone
1W2G crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with deoxythymidine (dt) (2.1 a resolution)Rv3247c2004-07-062005-01-12RELnone
1H5Z cytochrome p450 14 alpha-sterol demethylase (cyp51) from mycobacterium tuberculosis in ferric low-spin stateRv0764c2001-05-312003-10-03RELnone
3LP6 crystal structure of rv3275c-e60a from mycobacterium tuberculosis at 1.7a resolutionRv3275c2010-02-042010-06-16RELnone
1U5H structure of citrate lyase beta subunit from mycobacterium tuberculosisRv2498c TB:rv2498c2004-07-272004-10-12REL1U5V 1Z6K
3HA7 crystal structure of hma (mmaa4) from mycobacterium tuberculosis complexed with s-adenosyl-n-decyl-aminoethyl (sadae)Rv0642c2009-05-012009-05-12RELnone
1RQ7 mycobacterium tuberculosis ftsz in complex with gdprv2150c2003-12-042004-08-31RELnone
1DF7 dihydrofolate reductase of mycobacterium tuberculosis complexed with nadph and methotrexateRv2763c1999-11-172000-03-09REL1DG5 1DG7 1DG8 2CIG
3G5O the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2866) from mycobacterium tuberculosisRv2866 ISFI:ISFI120 ISFI:ISFI1212009-02-052009-04-14RELnone
1O6Y catalytic domain of pknb kinase from mycobacterium tuberculosisRv0014c NON-SPINE:IPRv0014cPALZ2002-10-212003-01-30RELnone
2WGS crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a purine analogue inhibitor.Rv22202009-04-272009-09-01RELnone
1ZA0 x-ray structure of putative acyl-acp desaturase desa2 from mycobacterium tuberculosis h37rvRv10942005-04-052005-06-07RELnone
2BYO crystal structure of mycobacterium tuberculosis lipoprotein lppx ( rv2945c)Rv2945c2005-08-032006-03-22RELnone
2G85 crystal structure of chorismate synthase from mycobacterium tuberculosis at 2.22 angstrons of resolutionRv2540c2006-03-012007-03-01RELnone
2BPQ anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (apo structure)Rv2192c2005-04-222006-01-04RELnone
3H6P crystal structure of rv3019c-rv3020c from mycobacterium tuberculosisRv3019c2009-04-232009-06-30RELnone
2A8X crystal structure of lipoamide dehydrogenase from mycobacterium tuberculosisRv04622005-07-102005-08-16RELnone
2B70 t4 lysozyme mutant l99a at ambient pressureRv2178c2005-10-032005-11-08REL2B7O
1N5I crystal structure of inactive mycobacterium tuberculosis thymidylate kinase complexed with thymidine monophosphate (tmp) at ph 4.6 (resolution 1.85 a)Rv3247c2002-11-062003-04-08RELnone
2AJ9 x-ray crystal structure of w42a,r161a double mutant of mycobacterium tuberculosis beta-ketoacyl-acp synthase iiiRv0533c2005-08-012005-08-30RELnone
1N3I crystal structure of mycobacterium tuberculosis pnp with transition state analog dadme-immhRv33072002-10-282003-09-30RELnone
1G3U crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with thymidine monophosphate (tmp)Rv3247c2000-10-252001-10-25REL1GSI 1GTV 1MRN 1MRS 1N5I 1N5J 1N5K 1N5L 1W2G 1W2H
2Z7A x-ray crystal structure of rv0760c from mycobacterium tuberculosis at 2.10 angstrom resolutionRv0760c2007-08-172007-09-11RELnone

Last updated: Feb 2 2012

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Sequence Redundancy Statistics

Table 5: Sequence Redundancy Statistics for TB by Experimental Status

Sequence Identity(%)Novel Targets
Status:
Selected		 Novel Targets
Status:
Cloned		 Novel Targets
Status:
Expressed 		Novel Targets
Status:
Purified		 Novel Targets
Status:
Crystallized		 Novel Targets
Status:
Crystal Structure		Novel Targets
Status:
NMR Structure		Novel Targets
Status:
in PDB
<100180013631030524368252209209
<98179913621029524368252209209
<95179413601028524368252209209
<90179213581026523367252209209
<70176913401017518362249206206
<5016671261977498354247205205
<4015471195932490346242203203
<301039918761453327231197193
Last updated: 12-01-10
Sequence redundancy is calculated by clustering analysis using BLASTClust program with similarity threshold set to percent of sequence identity.   Please view detailed explanation of sequence redundancy calculations and BLASTClust threshold settings.  Sequence redundancy calculations are based on comparison to all protein sequences in TargetDB which are in the same experimental status category and at least 20 amino acids long.

Table 6: Sequence Redundancy Statistics for Structures Released by TB by Year

Year Released Structures Number of Released Structures <30% Identity at Time of Release Percent(%) of Released Structures <30% Identity(%) at Time of Release
<= 200025416
20011616
200228311
200346920
2004691116
2005651929
2006881113
200752612
20084349
2009561018
2010500
Total4937816
Last updated: 12-02-02
Sequence redundancy is calculated by clustering analysis using BLASTClust program with similarity threshold set to percent of sequence identity.   Please view detailed explanation of sequence redundancy calculations and BLASTClust threshold settings.  Sequence redundancy calculations are based on comparison to all protein sequences in the PDB which are at least 20 amino acids long.
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