Want to be a Functional Sleuth? Functional Sleuth enables further research for proteins in the
Protein Data Bank archive whose functions are unknown or minimally characterized.
These "structures of unknown function" (SUFs) are organized by source organism. Select a domain/superkingdom or group (viruses, unclassified) to see all organisms that have SUFs; or jump to popular phyla or classes using the tree of life image below. Making a selection will launch an interactive tree browser. You can also download a text file of all SUF PDB IDs, updated weekly.
Right-click on any classification below to view the structure gallery and to download the list of PDB IDs an MS Excel-compatible format (CSV).
Provided below are galleries of PDB structures lacking functional annotation solved by the Protein Structure Initiative efforts. Click on a center name to expand or collapse its gallery. Clicking on a structure in a gallery will perform a query of the SBKB to provide a starting point for further study.